| Original Article |
Questions: 1. How well is the Pancreatitis Activity Scoring System (PASS) performing? 2. Does a modified PASS (mPASS) produce separate early trajectories between severity groupings and has a similar prediction accuracy?
Design/Method: An international prospective study under the name APPRENTICE was done between 2015 and 2018. Acute pancreatitis (AP) severity was categorized per the revised Atlanta classification. PASS trajectories were compared between the three severity groups using the generalized estimating equations model. Four mPASS models were generated by modifying the morphine equivalent dose (MED), and their trajectories were compared
Setting: North America, Europe, South America, and Asia
Patient/ Study community: 34-63 years old patients with AP, and characteristic epigastric pain, serum lipase >3 times upper limit of normal, and/or characteristic radiologic findings of AP
Results: PASS has its challenges because of its MED components. In contrast, mPASS preserves significantly unique early trajectories, forecasts severe AP with greater accuracy, and is simpler to calculate
Commentary:
| The MED component of the PASS is what makes it difficult to use as a worldwide AP activity metric. By eliminating MED components from PASS as a metric for AP activity, the mPASS index was created. For the dynamic monitoring of AP activity over time, this index maintains considerably unique trajectories while being less complex |
Citation: Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, et all. The Modified Pancreatitis Activity Scoring System Shows Distinct Trajectories in Acute Pancreatitis: An International Study. Clinical Gastroenterology and Hepatology. 2022; 20(6): 1334–1342
DOI: 10.1016/j.cgh.2021.09.014
https://pubmed.ncbi.nlm.nih.gov/34543736/
Topics: Acute Pancreatitis, Disease Activity, PASS, Severity
